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Case Reports
. 1987 Apr;84(7):1981-5.
doi: 10.1073/pnas.84.7.1981.

Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma

C Turc-Carel, P Dal Cin, J Limon, U Rao, F P Li, J M Corson, R Zimmerman, D M Parry, J M Cowan, A A Sandberg
Case Reports

Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma

C Turc-Carel et al. Proc Natl Acad Sci U S A. 1987 Apr.

Abstract

A translocation that involves chromosome X (band p11.2) and chromosome 18 (band q11.2) was observed in short-term in vitro cultures of cells from five synovial sarcomas and one malignant fibrous histiocytoma. In four of these tumors, the translocation t(X;18)(p11.2;q11.2) was reciprocal. The two other tumors had complex translocations: t(X;18;21)(p11.2;q11.2;p13) and t(X;15;18)(p11.2;q23;q11.2). A translocation between chromosomes X and 18 was not detected in other histological types of soft tissue sarcoma. The X;18 rearrangement appears to characterize the synovial sarcoma and is the first description of a primary, nonrandom change in the sex chromosome of a human solid tumor.

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References

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