Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Dec;6(12):1008-1010.
doi: 10.1016/j.jchf.2018.08.007. Epub 2018 Oct 10.

Pivotal Role of Excess Intra-Abdominal Adipose in the Pathogenesis of Metabolic/Obese HFpEF

Dalane W Kitzman  1 , Barbara J Nicklas  2
Affiliations
Editorial

Pivotal Role of Excess Intra-Abdominal Adipose in the Pathogenesis of Metabolic/Obese HFpEF

Dalane W Kitzman et al. JACC Heart Fail. 2018 Dec.
No abstract available

Keywords: abdominal fat; aging; heart failure with preserved ejection fraction; inflammation; obesity; visceral adipose tissue.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest:

Dr. Kitzman declares the following relationships: Consultant for Abbvie, Relypsa, Corvia Medical, CinRx, Boehringer-Ingelheim, and Bayer, research grant funding from Novartis, Bayer, St. Luke’s Hospital of Kansas City, GSK, and stock ownership in Gilead Sciences. Dr. Nicklas declares no conflicts of interest.

Comment in

Comment on

References

    1. Gomberg-Maitland M, Shah SJ, Guazzi M. Inflammation in Heart Failure With Preserved Ejection Fraction: Time to Put Out the Fire. JACC Heart Fail 2016; 4:325–8. - PubMed
    1. Kitzman DW, Brubaker P, Morgan T, et al. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomised clinical trial. JAMA 2016; 315:36–46. - PMC - PubMed
    1. Haykowsky MJ, Nicklas BJ, Brubaker PH, et al. Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction. JACC Heart Fail 2018; 6:640–9. - PMC - PubMed
    1. Lee MJ, Pramyothin P, Karastergiou K, Fried SK: Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity. Biochim Biophys Acta 2014,1842:473–81 - PMC - PubMed
    1. Kitzman DW, Lam C. Obese heart failure with preserved ejection phenotype: from Pariah to Central Player. Circulation 2017; 136:20–3. - PubMed