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. 2018 Dec;49(6):639-649.
doi: 10.1007/s10735-018-9801-4. Epub 2018 Oct 13.

Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy

Ahmed A M Abdel-Hamid  1 , Alaa El-Din L Firgany  2
Affiliations

Favorable outcomes of metformin on coronary microvasculature in experimental diabetic cardiomyopathy

Ahmed A M Abdel-Hamid et al. J Mol Histol. 2018 Dec.

Abstract

Although metformin is widely prescribed in diabetes, its use with associated cardiac dysfunction remains debatable. In the current study, we investigated the effect of metformin on coronary microvasculature in experimental diabetic cardiomyopathy (DCM) induced by streptozotocin. Administration of metformin after induction of DCM, reversed almost all cardiomyocyte degenerative changes induced by DCM. Metformin diminished the significantly increased (p < 0.05) collagen deposited in the DCM. In addition metformin had improved the density of the significantly decreased arteriolar (αSMA+) and capillary (CD31+) coronary microvasculature compared to that of the DCM and non-diabetics (ND) with downregulation of the significantly increased expression (p < 0.05) of COL-I, III, TGF-β, CTGF, ICAM and VCAM genes. Therefore metformin may be beneficial in limiting the fibrotic and the vascular remodeling occurring in DCM at the genetic as well as the structural levels.

Keywords: Cardiomyocyte steatosis; Coronary microcirculation; Diabetic cardiomyopathy; Fibrotic remodeling; Metformin; Vascular remodeling.

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References

    1. Diabetes. 2011 Jun;60(6):1770-8 - PubMed
    1. Biotechniques. 2001 Jan;30(1):38-40, 42 - PubMed
    1. Clin Hemorheol Microcirc. 2005;32(3):217-26 - PubMed
    1. J Mol Histol. 2015 Oct;46(4-5):337-45 - PubMed
    1. Biosci Rep. 2018 Feb 12;:null - PubMed

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