Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep 24:8:385.
doi: 10.3389/fonc.2018.00385. eCollection 2018.

Contemporary Management of 1-4 Brain Metastases

Sarah M C Sittenfeld  1 , John H Suh  1 , Erin S Murphy  1 , Jennifer S Yu  1 , Samuel T Chao  1
Affiliations
Review

Contemporary Management of 1-4 Brain Metastases

Sarah M C Sittenfeld et al. Front Oncol. .

Abstract

Brain metastases remain the most common neurologic complication of cancer. With improvement in surveillance and systemic therapy, patients with limited CNS disease are living longer after diagnosis, thus influencing the importance of optimal radiation treatment in order to maximize local control and minimize morbidity. In patients with a limited number of brain metastases, stereotactic radiosurgery is more recently seen as an appropriate sole modality for management with excellent local control. As newer systemic therapies emerge and with the advent of immunotherapies and targeted therapies for metastatic CNS disease, further research is needed in the optimal timing and sequencing of these modalities.

Keywords: brain metastases (BM); radiation therapy (XRT); review (article); stereotactic radiosurgery (SRS); systemic therapy.

PubMed Disclaimer

References

    1. Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet (2004) 363:1665–72. 10.1016/S0140-6736(04)16250-8 - DOI - PubMed
    1. Wen PY, Loeffler JS. Management of brain metastases. Oncology (1999) 13:941–54, 957–61; discussion: 961–2. - PubMed
    1. Le Chevalier T, Smith FP, Caille P, Constans JP, Rouesse JG. Sites of primary malignancies in patients presenting with cerebral metastases. a review of 120 cases. Cancer (1985) 56:880–82. 10.1002/1097-0142(19850815)56:4<880::AID-CNCR2820560430>3.0.CO;2-I - DOI - PubMed
    1. Suh JHCS, Peereboom DP, Barnett GH. Metastatic cancer to brain. In: DeVita VT, Lawrence TS, Rosenberg S. editiors. Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 10th ed Philadelphia, PA: Wolters Kluwer; (2015). p. 1832–1844.
    1. Suh JH. Stereotactic radiosurgery for the management of brain metastases. N Engl J Med. (2010) 362:1119–27. 10.1056/NEJMct0806951 - DOI - PubMed