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. 2018;66(2):579-586.
doi: 10.3233/JAD-180529.

The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study

Susanna C Larsson  1 , Alicja Wolk  1   2
Affiliations

The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study

Susanna C Larsson et al. J Alzheimers Dis. 2018.

Abstract

Background: The role of lifestyle factors and sleep for dementia is uncertain.

Objective: To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia.

Methods: We used data from a population-based cohort of 28,775 Swedish adults who were ≥65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Register.

Results: During a mean follow-up of 12.6 years, dementia was diagnosed among 3,755 participants (mean age at diagnosis 83.2±5.1 years). There were no associations of an overall healthy diet (defined by a modified Dietary Approaches to Stop Hypertension Diet score or a Mediterranean diet score), alcohol and coffee consumption, or physical activity with dementia incidence. Compared with never smokers, dementia risk was increased in former and current smokers (hazard ratio [95% confidence interval] = 1.13 [1.04-1.23] and 1.10 [1.00-1.21], respectively). Extended time of sleep (>9 h per night) was associated with an increased risk of dementia. However, this association appeared to be related to a reverse causation effect since the association did not remain after exclusion of cases diagnosed within the first five or ten years of follow-up.

Conclusions: This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia.

Keywords: Cohort studies; dementia; diet; lifestyle; prospective studies; sleep.

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Figures

Fig.1
Fig.1
Flow chart of participants.
See this image and copyright information in PMC

References

    1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 9, 63–75 e62. - PubMed
    1. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbaek G, Teri L, Mukadam N (2017) Dementia prevention, intervention, and care. Lancet 390, 2673–2734. - PubMed
    1. Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H (2015) Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimers Dement 11, 718–726. - PubMed
    1. Scarmeas N, Stern Y, Tang MX, Mayeux R, Luchsinger JA (2006) Mediterranean diet and risk for Alzheimer’s disease. Ann Neurol 59, 912–921. - PMC - PubMed
    1. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y (2009) Physical activity, diet, and risk of Alzheimer disease. JAMA 302, 627–637. - PMC - PubMed

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