Environment, Epigenetics, and Differential Responses to Beryllium Exposure: Are We There Yet?

Samuel Brusca¹, Sean Agbor-Enoh^{2

3

4}

Affiliations

¹ 1 Critical Care Medicine Department National Institutes of Health Clinical Center Bethesda, Maryland.
² 2 Division of Intramural Research National Heart, Lung and Blood Institute Bethesda, Maryland.
³ 3 Genomic Research Alliance for Transplantation (GRafT) Bethesda, Maryland and.
⁴ 4 Division of Pulmonary and Critical Care Medicine Johns Hopkins School of Medicine Baltimore, Maryland.

Editorial

Samuel Brusca et al. Am J Respir Cell Mol Biol. 2019 Jan.

. 2019 Jan;60(1):11-12.

doi: 10.1165/rcmb.2018-0306ED.

Samuel Brusca¹, Sean Agbor-Enoh^{2

3

4}

¹ 1 Critical Care Medicine Department National Institutes of Health Clinical Center Bethesda, Maryland.
² 2 Division of Intramural Research National Heart, Lung and Blood Institute Bethesda, Maryland.
³ 3 Genomic Research Alliance for Transplantation (GRafT) Bethesda, Maryland and.
⁴ 4 Division of Pulmonary and Critical Care Medicine Johns Hopkins School of Medicine Baltimore, Maryland.

No abstract available

Comment on

DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease.
Yang IV, Konigsberg I, MacPhail K, Li L, Davidson EJ, Mroz PM, Hamzeh N, Gillespie M, Silveira LJ, Fingerlin TE, Maier LA. Yang IV, et al. Am J Respir Cell Mol Biol. 2019 Jan;60(1):96-105. doi: 10.1165/rcmb.2018-0177OC. Am J Respir Cell Mol Biol. 2019. PMID: 30141971 Free PMC article.

1. Infante PF, Newman LS. Beryllium exposure and chronic beryllium disease. Lancet. 2004;363:415–416. - PubMed
1. Newman LS, Mroz MM, Balkissoon R, Maier LA. Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk. Am J Respir Crit Care Med. 2005;171:54–60. - PubMed
1. Sawyer RT, Fontenot AP, Barnes TA, Parsons CE, Tooker BC, Maier LA, et al. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007;36:191–200. - PMC - PubMed
1. Maier LA, McGrath DS, Sato H, Lympany P, Welsh K, Du Bois R, et al. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. J Immunol. 2003;171:6910–6918. - PubMed
1. Yang IV, Konigsberg I, MacPhail K, Li L, Davidson EJ, Mroz PM, et al. DNA methylation changes in lung immune cells are associated with granulomatous lung disease. Am J Respir Cell Mol Biol. 2019;60:96–105. - PMC - PubMed