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Editorial
. 2018 Oct 15;10(10):2544-2546.
doi: 10.18632/aging.101598.

Mutant ubiquitin reduces Aβ plaques

Bert M Verheijen  1 , Fred W van Leeuwen  1
Affiliations
Editorial

Mutant ubiquitin reduces Aβ plaques

Bert M Verheijen et al. Aging (Albany NY). .
No abstract available

Keywords: Alzheimer’s disease; Aβ plaques; amyloid β; mutant ubiquitin; proteostasis; ubiquitin-proteasome system; γ-secretase.

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Figures

Figure 1
Figure 1
Mutant ubiquitin (UBB+1) reduces Aβ plaques in APPPS1 mice. (A) Schematic diagram of amyloid precursor protein (APP) processing leading to Aβ. (B) γ-secretase is a multimeric enzyme complex that cleaves APP C-terminal fragment (CTF) to produce Aβ and an APP intracellular domain (AICD). (C) Transgenic APPPS1 mice carry two mutations that represent early-onset AD and develop age-related amyloid plaque pathology. (D) In APPPS1xUBB+1 mice, APP CTF-β levels are reduced and γ-secretase function is partially restored. (E) Besides secretases, alternate protein degradation pathways have been reported to degrade APP and Aβ.
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References

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