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Comment
. 2018 Nov 20;115(10):1837-1839.
doi: 10.1016/j.bpj.2018.09.023. Epub 2018 Oct 2.

Rigidity Rules in DNA Droplets: Nucleic Acid Flexibility Affects Model Membraneless Organelles

Alain A M André  1 , Evan Spruijt  2
Affiliations
Comment

Rigidity Rules in DNA Droplets: Nucleic Acid Flexibility Affects Model Membraneless Organelles

Alain A M André et al. Biophys J. .
No abstract available

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Figures

Figure 1
Figure 1
Four experimentally studied cases of the role of nucleic acid flexibility in model MLOs. ssDNAs with different persistence lengths are visualized at low and high salt. Droplets with rigid chains dissolve more easily than droplets with flexible chains. dsDNA forms aggregates at low salt and liquid droplets with liquid-crystalline ordering at high salt. Mixing DNA with free NTPs leads to subcompartments that contain the liquid-crystalline phase. To see this figure in color, go online.
See this image and copyright information in PMC

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