Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Nov;10(11):e9660.
doi: 10.15252/emmm.201809660.

Cancer immunotherapy in routine cost-effective cancer care?

Sir Marc Feldmann  1
Affiliations
Comment

Cancer immunotherapy in routine cost-effective cancer care?

Sir Marc Feldmann. EMBO Mol Med. 2018 Nov.

Abstract

Therapy‐triggered autoimmunity and inflammation in many cancer patients, as well as treatment costs, hamper the success of cancer immunotherapy. The study by Pfeiffer et al in this issue of EMBO Molecular Medicine constitutes a clear step towards a more simple, scalable and affordable approach in generating in situ T cells reprogrammed with chimeric antigen receptors (CARs) (Pfeiffer et al, 2018).

PubMed Disclaimer

Comment on

References

    1. Bender RR, Muth A, Schneider IC, Friedel T, Hartmann J, Pluckthun A, Maisner A, Bucholz CJ (2016) Receptor‐targeted nipah virus glycoproteins improve cell‐type selective gene delivery and reveal a preference for membrane‐proximal cell attachment. PLoS Pathog 12: e1005641 - PMC - PubMed
    1. Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, Rowland AM, Kotts C, Carver M, Shepard M (1992) Humanization of an anti‐p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 89: 4285–4289 - PMC - PubMed
    1. Eshhar Z, Waks T, Gross G, Schindler DG (1993) Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody‐binding domains and the gamma or zeta subunits of the immunoglobulin and T cell receptors. Proc Natl Acad Sci USA 90: 720–724 - PMC - PubMed
    1. Leach DR, Krummel MF, Allison JP (1996) Enhancement of anti‐tumor immunity by CTLA‐4 blockade. Science 271: 1734–1736 - PubMed
    1. Mellor JD, Brown MP, Irving HR, Zalcberg JR, Dobrovic A (2013) A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer. J Hematol Oncol 6: 1 - PMC - PubMed