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. 2018 Oct 30;115(44):11215-11220.
doi: 10.1073/pnas.1803630115. Epub 2018 Oct 15.

Intergenerational transmission of paternal trauma among US Civil War ex-POWs

Dora L Costa  1   2 , Noelle Yetter  2 , Heather DeSomer  2
Affiliations

Intergenerational transmission of paternal trauma among US Civil War ex-POWs

Dora L Costa et al. Proc Natl Acad Sci U S A. .

Abstract

We study whether paternal trauma is transmitted to the children of survivors of Confederate prisoner of war (POW) camps during the US Civil War (1861-1865) to affect their longevity at older ages, the mechanisms behind this transmission, and the reversibility of this transmission. We examine children born after the war who survived to age 45, comparing children whose fathers were non-POW veterans and ex-POWs imprisoned in very different camp conditions. We also compare children born before and after the war within the same family by paternal ex-POW status. The sons of ex-POWs imprisoned when camp conditions were at their worst were 1.11 times more likely to die than the sons of non-POWs and 1.09 times more likely to die than the sons of ex-POWs when camp conditions were better. Paternal ex-POW status had no impact on daughters. Among sons born in the fourth quarter, when maternal in utero nutrition was adequate, there was no impact of paternal ex-POW status. In contrast, among sons born in the second quarter, when maternal nutrition was inadequate, the sons of ex-POWs who experienced severe hardship were 1.2 times more likely to die than the sons of non-POWs and ex-POWs who fared better in captivity. Socioeconomic effects, family structure, father-specific survival traits, and maternal effects, including quality of paternal marriages, cannot explain our findings. While we cannot rule out fully psychological or cultural effects, our findings are most consistent with an epigenetic explanation.

Keywords: POW; epigenetics; intergenerational; mortality; reversibility.

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Conflict of interest statement

The authors declare no conflicts of interest.

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