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. 2018 Nov 26;62(12):e01137-18.
doi: 10.1128/AAC.01137-18. Print 2018 Dec.

Efficacy of Antifungal Monotherapies and Combinations against Aspergillus calidoustus

E Glampedakis #  1 , A T Coste #  2 , M Aruanno  2 , D Bachmann  2 , E Delarze  2 , V Erard  3 , F Lamoth  4   2
Affiliations

Efficacy of Antifungal Monotherapies and Combinations against Aspergillus calidoustus

E Glampedakis et al. Antimicrob Agents Chemother. .

Abstract

Invasive fungal infections due to Aspergillus calidoustus with decreased azole susceptibility are emerging in the setting of azole prophylaxis and are associated with poor outcomes. We assessed the in vitro activity of antifungal drugs used alone or in combinations against A. calidoustus and found a synergistic effect between voriconazole and terbinafine at concentrations within the therapeutic range. An invertebrate Galleria mellonella model of A. calidoustus infection tended to support the potential benefit of this combination.

Keywords: Aspergillus ustus; Galleria mellonella; Usti; amphotericin B; invasive fungal infections; synergism; terbinafine; voriconazole.

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Figures

FIG 1
FIG 1
Efficacy of antifungal drugs in a Galleria mellonella model of A. calidoustus infection. Survival curves of G. mellonella larvae injected with 3 × 106 spores of A. calidoustus and a single dose of antifungal drug 2-h postinfection. Larvae were monitored for survival twice daily. Groups of 20 larvae were used each time. (A and B) The results of two independent experiments. (C) Data were analyzed by Gehan-Breslow-Wilcoxon test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. PBS, phosphate-buffered saline (no drug); AMB, amphotericin B; VOR, voriconazole; TBF, terbinafine.
See this image and copyright information in PMC

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