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Review
. 2018 Oct 4:11:6415-6424.
doi: 10.2147/OTT.S167853. eCollection 2018.

LncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis

Jing Quan  1   2 , Xiang Pan  1   2 , Liwen Zhao  1   2 , Zuwei Li  1 , Kangfu Dai  2 , Fangli Yan  2 , Suyue Liu  2 , Hongfei Ma  2 , Yongqing Lai  1   2
Affiliations
Review

LncRNA as a diagnostic and prognostic biomarker in bladder cancer: a systematic review and meta-analysis

Jing Quan et al. Onco Targets Ther. .

Abstract

Background: Bladder cancer is one of the most common urinary malignancies, and has a high recurrence rate and poor outcomes. In order to identify novel diagnostic and prognostic biomarkers for bladder cancer, we conducted a meta-analysis to analyze the association between long non-coding RNA (lncRNA) expression and survival in bladder cancer.

Materials and methods: We searched literature from databases using our inclusion and exclusion criteria. STATA 14.0 software was used to analyze the data from collected studies and to construct the forest plots. A different effect size was selected for each meta-analysis.

Results: After selection, 30 articles were found to be eligible. The present meta-analysis contains data from 13 articles about clinicopathological characteristics, six articles about diagnosis, and 16 articles about prognosis. In the present study, we found that many lncRNAs could function as potential diagnostic and prognostic markers in bladder cancer. Among these findings, UCA1 was expected to be a diagnostic biomarker for bladder cancer, while the aberrant expression of HOTAIR and GAS5 was associated with poor disease-free survival/recurrence-free survival/disease-specific survival.

Conclusion: Overall, the present study is the first meta-analysis to assess the association between expression of lncRNAs and clinical value in patients with bladder cancer. LncRNAs hold promise as novel diagnostic and prognostic markers in bladder cancer.

Keywords: bladder cancer; clinicopathological characteristics; lncRNA; prognosis.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The study selection process. Abbreviation: lncRNA, long non-coding RNA.
Figure 2
Figure 2
Forest plot of sensitivity and specificity of lncRNAs for the diagnosis of bladder cancer. Abbreviation: lncRNA, long non-coding RNA.
Figure 3
Figure 3
Deeks’ funnel plot asymmetry test for publication.
Figure 4
Figure 4
The summary receiver operator characteristic (SROC) curve based on UCA1. Abbreviations: SEN, sensitivity; SPE, specificity; SROC, summary receiver operator characteristic.
See this image and copyright information in PMC

References

    1. Babjuk M, Böhle A, Burger M, et al. EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016. Eur Urol. 2017;71(3):447–461. - PubMed
    1. Kubota Y, Nakaigawa N. Committee for Establishment of the Clinical Practice Guideline for the Management of Bladder Cancer and the Japanese Urological Association. Essential content of evidence-based clinical practice guidelines for bladder cancer: The Japanese Urological Association 2015 update. Int J Urol. 2016;23(8):640–645. - PubMed
    1. Clark PE, Spiess PE, Agarwal N, et al. NCCN Guidelines Insights: Bladder Cancer, Version 2.2016. J Natl Compr Canc Netw. 2016;14(10):1213–1224. - PMC - PubMed
    1. Gutschner T, Diederichs S. The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012;9(6):703–719. - PMC - PubMed
    1. Wapinski O, Chang HY. Long noncoding RNAs and human disease. Trends Cell Biol. 2011;21(6):354–361. - PubMed