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Review
. 2018 Sep 1;8(9):1674-1688.
eCollection 2018.

The fundamental role of miR-10b in metastatic cancer

Patrick Sheedy  1 , Zdravka Medarova  2
Affiliations
Review

The fundamental role of miR-10b in metastatic cancer

Patrick Sheedy et al. Am J Cancer Res. .

Abstract

Small, non-coding strands of RNA have been identified as a significant player in the pathology of cancer. One of the first miRNAs to be shown as having aberrant expression in cancer was miR-10b. Since the inaugural study on miR-10b, its role as a metastasis promoting factor has been extensively validated. To date, more than 100 studies have been completed on miR-10b and metastasis across 18 cancer types. This immense set of information holds possibilities for novel methods to improve the lives of many. This review outlines what is currently understood of miR-10b's clinical significance, its molecular regulation, and the possible diagnostic and therapeutic methods leveraging miR-10b as a fundamental target in metastatic cancer. Such methods would move us closer to developing a truly individualized therapeutic strategy against cancer and will likely provide unique information about cancer staging, disease outcome, metastatic potential, and ultimately survival.

Keywords: Metastasis; cancer; epithelial-to-mesenchymal transition; microRNA-10b.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Molecular pathways of miR-10b regulation.
See this image and copyright information in PMC

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