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. 2018 Dec;41(12):877-879.
doi: 10.1016/j.tins.2018.09.011. Epub 2018 Oct 13.

Inflammation after Stroke: A Local Rather Than Systemic Response?

Ruslan Rust  1 , Lisa Grönnert  2 , Martin E Schwab  3
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Inflammation after Stroke: A Local Rather Than Systemic Response?

Ruslan Rust et al. Trends Neurosci. 2018 Dec.

Abstract

After injury, activation and recruitment of inflammatory and immune cells has been thought to occur throughout the whole body. A recent study shows that after brain injury in mice, immune cells are primarily recruited from nearby skull bone marrow and invade the brain through microscopic vascular channels. Manipulation of this process may provide new therapeutic options.

Keywords: immune cell recruitment; ischemia; neutrophils; vascular channels.

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