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. 1987 May;76(1):66-72.
doi: 10.1007/BF00283053.

Human ferritin H and L sequences lie on ten different chromosomes

J R McGill, S L Naylor, A Y Sakaguchi, C M Moore, D Boyd, K J Barrett, T B Shows, J W Drysdale

Human ferritin H and L sequences lie on ten different chromosomes

J R McGill et al. Hum Genet. 1987 May.

Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chromosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

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