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. 2019 Jan;94(1):E8-E11.
doi: 10.1002/ajh.25321. Epub 2018 Nov 9.

Platelet sequestration and consumption in the placental intervillous space contribute to lower platelet counts during pregnancy

Jessica A Reese  1   2 , Jennifer D Peck  1 , Zhongxin Yu  3 , Teresa A Scordino  3 , David R Deschamps  4 , Jennifer J McIntosh  4 , Deirdra R Terrell  1 , Sara K Vesely  1 , James N George  1   2
Affiliations

Platelet sequestration and consumption in the placental intervillous space contribute to lower platelet counts during pregnancy

Jessica A Reese et al. Am J Hematol. 2019 Jan.
No abstract available

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Conflict of interest statement

Conflict of Interest and Financial Disclosure: All authors have no conflicts of interest or financial conflicts with this study.

Figures

Figure 1.
Figure 1.
Placental morphology and immunohistochemical staining of sections of a placenta obtained at delivery and included in this study. Placental sections were stained with hematoxylin and eosin (H&E) to demonstrate the structure of the villi and perivillous fibrinoid, and also with a rabbit anti-CD61 (platelet membrane glycoprotein IIIa) monoclonal antibody by ProPath referral pathology service, Dallas, TX. A. Lowmagnification view of the placental parenchyma illustrating mature terminal villi. Perivillous fibrinoid filling gaps in the syncytiotrophoblast surface of the villi are identified by the homogeneous pink stain. Representative examples of the perivillous fibrinoid are indicated by the arrows. (H&E, 10X objective) B. An adjacent location in the same placental section stained with anti-CD61 (brown color) demonstrating platelets within the perivillous fibrinoid, in a linear pattern along the villous surfaces throughout this section. Representative examples of platelet staining are indicated by the arrows. (CD61 immunostaining, 10X objective) C. High-magnification of the placental parenchyma illustrates a mature terminal villus. The arrow indicates perivillous fibrinoid sealing a gap in the syncytiotrophoblast surface. (H&E, 100X objective) D. An adjacent location stained with anti-CD61 (brown color) demonstrating platelets within the perivillous fibrinoid, indicated by the arrow. (CD61 immunostaining, 100X objective)
See this image and copyright information in PMC

References

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