doi: 10.1099/0022-1317-68-5-1435.
Virulence is not conserved in recombinants between herpes simplex virus types 1 and 2
- PMID: 3033143
- DOI: 10.1099/0022-1317-68-5-1435
Item in Clipboard
Virulence is not conserved in recombinants between herpes simplex virus types 1 and 2
J Gen Virol.
1987 May.
Abstract
The virulence of 31 herpes simplex virus type 1 X herpes simplex virus type 2 intertypic recombinants was determined following intraperitoneal inoculation into CBA mice. Only eight of the recombinants killed any of the mice and of these, only one recombinant was as virulent as its type 2 parent, the other seven recombinants being intermediate between their type 1 and type 2 parental viruses in virulence. These results indicate that most heterotypic combinations are attenuated independently of the virulence of the parental viruses and therefore that the virulence of HSV is controlled multigenically.
Similar articles
-
Multigenic control of virus virulence in intertypic recombinants of herpes simplex virus.Indian J Exp Biol. 1990 Oct;28(10):960-3. Indian J Exp Biol. 1990. PMID: 2177726
-
A variant of herpes simplex virus type 2 strain HG52 with a 1.5 kb deletion in RL between 0 to 0.02 and 0.81 to 0.83 map units is non-neurovirulent for mice.J Gen Virol. 1989 Mar;70 ( Pt 3):705-16. doi: 10.1099/0022-1317-70-3-705. J Gen Virol. 1989. PMID: 2543755
-
Investigation of the virulence genes of herpes simplex virus 2 by experimental infection in vivo with defined intertypic recombinants of a virulent HSV-2 X an avirulent HSV-1.Med Microbiol Immunol. 1985;174(5):237-48. doi: 10.1007/BF02124808. Med Microbiol Immunol. 1985. PMID: 3003551
-
Herpes simplex virus infections: new concepts in an old disease.Dermatologica. 1989;178(1):1-5. doi: 10.1159/000248375. Dermatologica. 1989. PMID: 2537238 Review.
-
[Problems in the pathogenesis of Herpes simplex virus infections].Bratisl Lek Listy. 1970 Mar;53(3):353-63. Bratisl Lek Listy. 1970. PMID: 4317338 Review. Slovak. No abstract available.
Cited by
-
In vitro-generated interspecific recombinants between bovine herpesviruses 1 and 5 show attenuated replication characteristics and establish latency in the natural host.BMC Vet Res. 2011 May 18;7:19. doi: 10.1186/1746-6148-7-19. BMC Vet Res. 2011. PMID: 21592326 Free PMC article.
-
Experimental in vivo generation of intertypic recombinant strains of HSV in the mouse.Arch Virol. 1992;125(1-4):227-38. doi: 10.1007/BF01309640. Arch Virol. 1992. PMID: 1322653
-
Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.J Clin Microbiol. 1992 Mar;30(3):655-62. doi: 10.1128/jcm.30.3.655-662.1992. J Clin Microbiol. 1992. PMID: 1551982 Free PMC article.
-
An acyclovir-resistant strain of herpes simplex virus type 2 which is highly virulent for mice.Arch Virol. 1988;101(3-4):169-82. doi: 10.1007/BF01310998. Arch Virol. 1988. PMID: 2845890
-
An intertypic herpes simplex virus helicase-primase complex associated with a defect in neurovirulence has reduced primase activity.J Virol. 1998 Feb;72(2):1203-9. doi: 10.1128/JVI.72.2.1203-1209.1998. J Virol. 1998. PMID: 9445019 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
