Effect of converting enzyme inhibitors on hypertensive large arteries in humans

Abstract

As demonstrated in hypertensive humans on the basis of non-invasive Doppler methods, converting enzyme inhibitors (CEI) dilate not only small arteries but also large arteries, particularly in the brachial and the carotid circulations. The dilating effect of CEI on large arteries is associated with an enhancement of systemic and brachial arterial compliance, implying a particular action of the drug on arterial smooth muscle. Converting enzyme inhibitors are thus able to reverse the reduced arterial compliance observed in patients with essential hypertension.