Competing interests: Dr. Nickel has been a consultant for Astellas, Auxillium, Eli Lilly, Farr Labs, Ferring, GSK, Pfizer, Redleaf Pharma, Taris Biomedical, Tribute, and Trillium Therapeutics; a lecturer for Astellas and Eli Lilly; and has participated in clinical trials supported by Eli Lilly, GSK, J&J, Pfizer, and Taris Biomedical. Dr. Aaron has attended advisory boards for AbbVie and Janssen; has been a speaker for Ferring and Janssen; holds investments in Johnson & Johnson; and has participated in clinical trials supported by Asetllas, Ferring, and Janssen. Dr. Elterman has attended advisory boards for, is a speaker for, and has received grant funding from Allergan, Astellas, Boston Scientific, Ferring, Medtronic, and Pfizer; and has participated in clinical trials supported by Astellas and Medtronic. Dr. Zorn has received honoraria from Boston Scientific and as a proctor/lecturer for Greenlight; and participated in the WATER2 clinical trial with aquablation supported by Procept Biorobotics. The remaining authors report no competing personal or financial interests.