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Comment
. 2018 Oct 16;49(4):590-592.
doi: 10.1016/j.immuni.2018.09.022.

Basal Instinct: Persistence of Barrier Dysfunction

Caroline Chauché  1 , Henry J McSorley  2
Affiliations
Free article
Comment

Basal Instinct: Persistence of Barrier Dysfunction

Caroline Chauché et al. Immunity. .
Free article

Abstract

In a recent issue of Nature, Ordovas-Montanes et al. (2018) used cutting-edge genomic, epigenetic, and interventional techniques to characterize the cellular ecosystem in allergic chronic rhinosinusitis. They showed that basal epithelial cells "remember" type 2 inflammatory stimuli to maintain a chronic allergic disease phenotype.

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  • Allergic inflammatory memory in human respiratory epithelial progenitor cells.
    Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH 2nd, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Ordovas-Montanes J, et al. Nature. 2018 Aug;560(7720):649-654. doi: 10.1038/s41586-018-0449-8. Epub 2018 Aug 22. Nature. 2018. PMID: 30135581 Free PMC article.