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. 1987 May;61(5):1647-50.
doi: 10.1128/JVI.61.5.1647-1650.1987.

Effect of internal viral sequences on the utility of retroviral vectors

D Armentano, S F Yu, P W Kantoff, T von Ruden, W F Anderson, E Gilboa

Effect of internal viral sequences on the utility of retroviral vectors

D Armentano et al. J Virol. 1987 May.

Abstract

Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus.

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References

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