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. 1987 May;61(5):1686-9.
doi: 10.1128/JVI.61.5.1686-1689.1987.

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

D Smotkin, F O Wettstein

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

D Smotkin et al. J Virol. 1987 May.

Abstract

In a previous study, the most abundant viral transcript in a human papillomavirus type 16-associated cervical cancer and in a cancer-derived cell line was characterized, and its translation product, the E7 protein, was identified (D. Smotkin and F. O. Wettstein, Proc. Natl. Acad. Sci. USA 68:4680-4684, 1986). Here we show that the E7 protein had a half life of about 1 h and was located in the soluble cytoplasmic fraction. The protein was phosphorylated at serine residues and exhibited a high heterogeneous sedimentation rate in nondenaturing glycerol gradients, suggesting an oligomer formation or association with cellular protein.

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