Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 May;61(5):1686-9.
doi: 10.1128/JVI.61.5.1686-1689.1987.

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

D Smotkin, F O Wettstein

The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein

D Smotkin et al. J Virol. 1987 May.

Abstract

In a previous study, the most abundant viral transcript in a human papillomavirus type 16-associated cervical cancer and in a cancer-derived cell line was characterized, and its translation product, the E7 protein, was identified (D. Smotkin and F. O. Wettstein, Proc. Natl. Acad. Sci. USA 68:4680-4684, 1986). Here we show that the E7 protein had a half life of about 1 h and was located in the soluble cytoplasmic fraction. The protein was phosphorylated at serine residues and exhibited a high heterogeneous sedimentation rate in nondenaturing glycerol gradients, suggesting an oligomer formation or association with cellular protein.

PubMed Disclaimer

References

    1. Virology. 1985 Aug;145(1):105-16 - PubMed
    1. J Mol Biol. 1985 Apr 20;182(4):541-54 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Jul;82(14):4568-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Dec;82(23):7952-4 - PubMed
    1. J Virol. 1986 Jun;58(3):979-82 - PubMed

Publication types