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. 1987 May;61(5):1700-3.
doi: 10.1128/JVI.61.5.1700-1703.1987.

Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice

A Puga, A L Notkins

Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice

A Puga et al. J Virol. 1987 May.

Abstract

Radioactively labeled cDNAs were prepared by using as the template poly(A)+ mRNA from trigeminal ganglia of mice latently infected with herpes simplex virus type 1. These cDNAs were used as hybridization probes for Southern blots of cloned herpes simplex virus type 1 DNA fragments. Specific hybridization to fragments from the terminal repetition of the L segment was detected with probes derived from mRNAs obtained as early as 3 weeks and as late as 17 months postinoculation. Fine mapping of the region of hybridization showed that the viral transcripts originated from DNA sequences coding for the immediate-early gene IE-1 (alpha-0). These results indicate that IE-1, or an as yet unidentified gene colinear with it, is continuously expressed during latency.

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