doi: 10.1128/JVI.61.5.1743-1746.1987.
Replication of latent Epstein-Barr virus genomes in Raji cells
- PMID: 3033303
- PMCID: PMC254169
- DOI: 10.1128/JVI.61.5.1743-1746.1987
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Replication of latent Epstein-Barr virus genomes in Raji cells
J Virol.
1987 May.
Abstract
The replication of the 50 to 60 latent, predominantly extrachromosomal, Epstein-Barr virus genomes maintained by the Burkitt-lymphoma-derived Raji cell line was investigated by using a Meselson-Stahl density transfer approach. Samples of DNA isolated from cells cultivated for different periods in bromodeoxyuridine-supplemented medium were fractionated according to density, and the distribution of viral and cellular DNAs among the heavy-, hybrid-, and light-density species was quantitated. The results indicate that the majority of latent Epstein-Barr virus DNA plasmids each replicate once during the cell cycle.
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