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Case Reports
. 2018 Nov;24(11):1998-2002.
doi: 10.3201/eid2411.180787.

Cryptococcus gattii Complex Infections in HIV-Infected Patients, Southeastern United States

Kaylee T Bruner, Carlos Franco-Paredes, Andrés F Henao-Martínez, Gregory M Steele, Daniel B Chastain
Case Reports

Cryptococcus gattii Complex Infections in HIV-Infected Patients, Southeastern United States

Kaylee T Bruner et al. Emerg Infect Dis. 2018 Nov.

Abstract

Cryptococcus gattii traditionally infects immunocompetent hosts and causes devastating pulmonary or central nervous system disease. However, this infection rarely occurs in patients infected with HIV. We report 3 cases of HIV-associated C. gattii complex infections in the southeastern United States. Detection of C. gattii in HIV-infected patients in this region warrants increased awareness of this threat to ensure appropriate diagnosis and treatment to optimize patient outcomes.

Keywords: Cryptococcus; Cryptococcus gattii; Cryptococcus gattii complex; HIV-infected patients; HIV/AIDS and other retroviruses; Pacific Northwest; United States; case series; fungi; infections; meningitis/encephalitis; southeastern United States; southwestern Georgia; virus.

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Figures

Figure
Figure
Computed tomography images of the chest of an HIV-infected 47-year-old man (case-patient 3) with Cryptococcus gattii complex infection, southeastern United States. Transverse (A) and frontal (B) views without intravenous contrast showed a mass (arrows) (4.0 cm × 2.5 cm) that had central cavitation posteriorly in the right lower lobe abutting the pleural surface. The central cavitary portion of this lesion had a maximum length of ≈1.3 cm and no evidence of fluid level or internal soft tissues
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