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. 2018 Nov;24(11):2109-2111.
doi: 10.3201/eid2411.171929.

Burkholderia lata Infections from Intrinsically Contaminated Chlorhexidine Mouthwash, Australia, 2016

Lex E X Leong, Diana Lagana, Glen P Carter, Qinning Wang, Kija Smith, Tim P Stinear, David Shaw, Vitali Sintchenko, Steven L Wesselingh, Ivan Bastian, Geraint B Rogers

Burkholderia lata Infections from Intrinsically Contaminated Chlorhexidine Mouthwash, Australia, 2016

Lex E X Leong et al. Emerg Infect Dis. 2018 Nov.

Abstract

Burkholderia lata was isolated from 8 intensive care patients at 2 tertiary hospitals in Australia. Whole-genome sequencing demonstrated that clinical and environmental isolates originated from a batch of contaminated commercial chlorhexidine mouthwash. Genomic analysis identified efflux pump-encoding genes as potential facilitators of bacterial persistence within this biocide.

Keywords: Australia; Burkholderia lata; bacteria; chlorhexidine mouthwash; genome analysis; intensive care unit; nosocomial infections.

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Figures

Figure
Figure
Phylogenetic analysis of isolates implicated in an outbreak Burkholderia lata infection from intrinsically contaminated chlorhexidine mouthwash, Australia, 2016. The maximum-likelihood tree is constructed from core genome single-nucleotide polymorphism alignments (N = 512,480) of the outbreak genomes, bootstrapped 1,000 times, and archival genomes from B. cepacia complex group K, relative to the reference genome B. lata A05 (identified by an asterisk). B. metallica was included as a comparator.
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