Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2019 Jul 2;69(2):332-340.
doi: 10.1093/cid/ciy901.

Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study

Damien Contou  1   2   3 , Florence Canoui-Poitrine  4   5 , Rémi Coudroy  6 , Sébastien Préau  7 , Martin Cour  8 , François Barbier  9 , Nicolas Terzi  10 , Guillaume Schnell  11 , Arnaud Galbois  12 , Lara Zafrani  13 , Benjamin Zuber  14 , Stephan Ehrmann  15 , Elodie Gelisse  16 , Delphine Colling  17 , Matthieu Schmidt  18 , Samir Jaber  19 , Alexandre Conia  20 , Romain Sonneville  21 , Gwenhaël Colin  22 , Laurent Guérin  23 , Damien Roux  24 , Sébastien Jochmans  25 , Nancy Kentish-Barnes  26 , Etienne Audureau  4   5 , Richard Layese  4   5 , Aline Alves  1 , Rachida Ouedraogo  1 , Christian Brun-Buisson  1 , Armand Mekontso Dessap  1   3 , Nicolas de Prost  1   3 ; Hopeful Study Group
Collaborators, Affiliations
Free article
Multicenter Study

Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study

Damien Contou et al. Clin Infect Dis. .
Free article

Abstract

Background: Long-term health-related quality of life (HR-QOL) of patients surviving the acute phase of purpura fulminans (PF) has not been evaluated.

Methods: This was a French multicenter exposed-unexposed cohort study enrolling patients admitted in 55 intensive care units (ICUs) for PF from 2010 to 2016. Adult patients surviving the acute phase of PF (exposed group) were matched 1:1 for age, sex, and Simplified Acute Physiology Score II with septic shock survivors (unexposed group). HR-QOL was assessed during a phone interview using the 36-Item Short-Form Health Survey (SF-36) questionnaire, the Hospital Anxiety and Depression (HAD) scale, the Impact of Event Scale-Revised (IES-R), and the activity of daily living (ADL) and instrumental ADL (IADL) scales. The primary outcome measure was the physical component summary (PCS) of the SF-36 questionnaire.

Results: Thirty-seven survivors of PF and 37 of septic shock were phone-interviewed at 55 (interquartile range [IQR], 35-83) months and 44 (IQR, 35-72) months, respectively, of ICU discharge (P = .23). The PCS of the SF-36 was not significantly different between exposed and unexposed patients (median, 47 [IQR, 36-53] vs 54 [IQR, 36-57]; P = .18). There was also no significant difference between groups regarding the mental component summary of the SF-36, and the HAD, IES-R, ADL and IADL scales. Among the 37 exposed patients, those who required limb amputation (n = 12/37 [32%]) exhibited lower PCS (34 [IQR, 24-38] vs 52 [IQR, 42-56]; P = .001) and IADL scores (7 [IQR, 4-8] vs 8 [IQR, 7-8]; P = .021) compared with nonamputated patients.

Conclusions: Long-term HR-QOL does not differ between patients surviving PF and those surviving septic shock unrelated to PF. Amputated patients have an impaired physical HR-QOL but a preserved mental health.

Clinical trials registration: NCT03216577.

Keywords: SF-36; outcome; purpura fulminans; quality of life; septic shock.

PubMed Disclaimer

Publication types

Associated data