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. 1987 Feb;12(2):141-7.
doi: 10.1007/BF00979530.

Neurochemical evidence for two types of presynaptic alpha 2-adrenoceptors

J Kapocsi, G T Somogyi, N Ludvig, P Serfozo, L G Harsing Jr, R J Woods, E S Vizi

Neurochemical evidence for two types of presynaptic alpha 2-adrenoceptors

J Kapocsi et al. Neurochem Res. 1987 Feb.

Abstract

Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha 2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha 2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha 2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha 2-adrenoceptors at the presynaptic axon terminals.

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