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. 2019 Mar 1;199(5):564-571.
doi: 10.1164/rccm.201806-1053PP.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection

Salmaan Keshavjee  1   2 , Farhana Amanullah  3 , Adithya Cattamanchi  4 , Richard Chaisson  5 , Karen M Dobos  6 , Gregory J Fox  7 , Howard E Gendelman  8 , Richard Gordon  9 , Anneke Hesseling  10 , Hoi Le Van  11   12 , Beate Kampmann  13 , Bavesh Kana  14   15 , Gopal Khuller  16 , David M Lewinsohn  17   18 , Deborah A Lewinsohn  17 , Philiana Ling Lin  19 , Lenette Lin Lu  20 , Gary Maartens  21 , Andrew Owen  22 , Marina Protopopova  23 , Jyothi Rengarajan  24 , Eric Rubin  25 , Padmini Salgame  26 , Erwin Schurr  27 , James A Seddon  13 , Susan Swindells  8 , David M Tobin  28 , Zarir Udwadia  29 , Gerhard Walzl  30   14 , Sudha Srinivasan  23 , Roxana Rustomjee  23 , Payam Nahid  4
Affiliations

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection

Salmaan Keshavjee et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Spectrum of clinical states that comprise asymptomatic tuberculosis (TB) infection. Shown are the various manifestations of infection with Mycobacterium tuberculosis, before the diagnosis of active TB. The spectrum of TB-infected states, which were previously all characterized as latent TB infection, represents a diversity of outcomes on exposure to infectious particles. This appreciation of clinical complexity has been largely driven by the development of biomarkers to monitor risk of disease progression and refined imaging techniques. Text below the graphic details areas of investigation necessary to better characterize the latency spectrum, including study of bacterial physiology, novel diagnostics, HDTs, new therapeutic options, and host immunity. The ultimate goal of further understanding the spectrum of TB infection is to develop interventions that prevent progression to active TB disease. H = isoniazid; HDT = host-directed therapies; IGRA = IFN-γ release assay; LTA4H = leukotriene A(4) hydrolase; P = rifapentine; R = rifampin; TLR2 = Toll-like receptor 2; TST = tuberculin skin test.
See this image and copyright information in PMC

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