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. 1987 Apr 24;15(8):3305-15.
doi: 10.1093/nar/15.8.3305.

All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs

D V Sangar, S E Newton, D J Rowlands, B E Clarke
Free PMC article

All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs

D V Sangar et al. Nucleic Acids Res. .
Free PMC article

Abstract

Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used is the concentration of Mg2+.

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