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. 2018 Oct 17;10(10):1527.
doi: 10.3390/nu10101527.

Effect of Consumption Heated Oils with or without Dietary Cholesterol on the Development of Atherosclerosis

Che Anishas Che Idris  1 , Kalyana Sundram  2 , Ahmad Faizal Abdull Razis  3   4   5
Affiliations

Effect of Consumption Heated Oils with or without Dietary Cholesterol on the Development of Atherosclerosis

Che Anishas Che Idris et al. Nutrients. .

Erratum in

Abstract

Heating oils and fats for a considerable length of time results in chemical reactions, leading to the aggravation of a free radical processes, which ultimately contributes to atherosclerosis. Our study focused on elucidating the effect of feeding heated oils with or without dietary cholesterol on the development of atherosclerosis in rabbits. We heated palm olein and corn oil at 180 °C for 18 h and 9 h per day, respectively, for two consecutive days. Next, 20 male rabbits were divided into four groups and fed the following diet for 12 weeks: (i) heated palm olein (HPO); (ii) HPO with cholesterol (HPOC); (iii) heated corn oil (HCO); and (iv) HCO with cholesterol (HCOC). Plasma total cholesterol (TC) was significantly lower in the HCO group compared to the HCOC group. Atherosclerotic lesion scores for both fatty plaques and fatty streaks were significantly higher in the HCO and HCOC groups as compared to the HPO and HPOC groups. Additionally, fibrous plaque scores were also higher in the HCO and HCOC groups as compared to the HPO and HPOC groups. These results suggest that heated palm oil confers protection against the onset of atherosclerosis compared to heated polyunsaturated oils in a rabbit model.

Keywords: atherosclerosis; cholesterol; corn oil; heated fats; palm olein.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL-C), and low-density lipoproteins levels (LDL-C) of rabbits in the four dietary groups. Values are presented in means ± SD and means with similar letters differ significantly (p < 0.05). Heated palm olein (HPO); heated palm olein with added dietary cholesterol (HPOC); heated corn oil (HCO); heated corn oil with added dietary cholesterol (HCOC). Similar letters differ significantly.
Figure 2
Figure 2
ABTS (2,2′-azinobis (3-ethylbenzothiazoline) 6-sulfonic acid radical cation) and ferric reducing ability of plasma (FRAP) levels of rabbits in the four dietary groups. Values are presented in means ± SD and means with similar letters differ significantly (p < 0.05). Similar letters differ significantly.
Figure 3
Figure 3
Percentage of fibrous plaques, fatty plaques and fatty streaks in the aortas of rabbits in the four dietary groups. Values are presented in means ± SD and means with similar letters differ significantly (p < 0.05). Similar letters differ significantly.
Figure 4
Figure 4
Photographs of aortic lesions in rabbits fed diet with and without added dietary cholesterol in different groups (A) HPO, (B) HPOC, (C) HCO, and (D) HCOC. Development of atherosclerosis is shown as (I) fibrous plaques, (II) fatty plaques, and (III) fatty streaks.
See this image and copyright information in PMC

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