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. 1987 May;84(9):2848-52.
doi: 10.1073/pnas.84.9.2848.

Avian sarcoma virus 17 carries the jun oncogene

Y Maki, T J Bos, C Davis, M Starbuck, P K Vogt

Avian sarcoma virus 17 carries the jun oncogene

Y Maki et al. Proc Natl Acad Sci U S A. 1987 May.

Abstract

Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.

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