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Comparative Study
. 1987 Feb;26(2):203-6.
doi: 10.1016/0091-3057(87)90105-5.

The effect of chronic imipramine and electroconvulsive shock treatment on [3H]DADLE binding to cortical membranes of rats pretreated with chronic reserpine or 6-hydroxydopamine

L Antkiewicz-Michaluk, J Michaluk, A Rokosz-Pelc, D Marona-Lewicka, J Vetulani
Comparative Study

The effect of chronic imipramine and electroconvulsive shock treatment on [3H]DADLE binding to cortical membranes of rats pretreated with chronic reserpine or 6-hydroxydopamine

L Antkiewicz-Michaluk et al. Pharmacol Biochem Behav. 1987 Feb.

Abstract

Repetitive electroconvulsive shock treatment (for 8 days) or chronic administration of imipramine (10 mg/kg/day IP for 14 or 21 days) elevated the density of opioid delta receptors in the cerebral cortex of the rat. Electroconvulsive shock treatment produced a similar effect in rats treated subchronically with reserpine or receiving intraventricularly 6-hydroxydopamine, but these manipulations of central catecholamines prevented the action of imipramine.

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