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Comment
. 2018 Nov 6;115(45):11357-11359.
doi: 10.1073/pnas.1815756115. Epub 2018 Oct 18.

Natural killer cells might adapt their inhibitory receptors for memory

Megan A Cooper  1
Affiliations
Comment

Natural killer cells might adapt their inhibitory receptors for memory

Megan A Cooper. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Rag-deficient mice were sensitized with peptides by Wight et al. (1) to test NK cell antigen-specific recall responses in a model of CHS. While previous studies demonstrated strict specificity for antigens, these investigators found that peptides sharing the same amino acids at positions 2 and 3, thought to bind NK cell Ly49C, exhibited cross-reactivity.
See this image and copyright information in PMC

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References

    1. Wight A, et al. Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses. Proc Natl Acad Sci USA. 2018;115:11579–11584. - PMC - PubMed
    1. O’Leary JG, Goodarzi M, Drayton DL, von Andrian UH. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol. 2006;7:507–516. - PubMed
    1. Paust S, et al. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010;11:1127–1135. - PMC - PubMed
    1. Cooper MA, et al. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci USA. 2009;106:1915–1919. - PMC - PubMed
    1. Sun JC, Beilke JN, Lanier LL. Adaptive immune features of natural killer cells. Nature. 2009;457:557–561. - PMC - PubMed

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