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. 2018 Sep 10;5(10):ofy222.
doi: 10.1093/ofid/ofy222. eCollection 2018 Oct.

Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children

Kathleen Chiotos  1   2   3 , Pranita D Tamma  4 , Kelly B Flett  5 , Manjiree V Karandikar  5 , Koorosh Nemati  4 , Warren B Bilker  6   7   8   9 , Theoklis Zaoutis  1   3   6   7 , Jennifer H Han  6   7   10
Affiliations

Increased 30-Day Mortality Associated With Carbapenem-Resistant Enterobacteriaceae in Children

Kathleen Chiotos et al. Open Forum Infect Dis. .

Abstract

In this multicenter study, we identified an increased risk of 30-day mortality among hospitalized children with carbapenem-resistant Enterobacteriaceae (CRE) isolated from clinical cultures compared with those with carbapenem-susceptible Enterobacteriaceae. We additionally report significant variation in antibiotic treatment for children with CRE infections with infrequent use of combination therapy.

Keywords: Gram-negative resistance; Klebsiella pneumoniae carbapenemase; multidrug-resistant organism; pediatrics.

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