Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Nov;28(6):1413-1420.
doi: 10.1007/s10895-018-2310-8. Epub 2018 Oct 18.

Rationally Designed Fluorescent pH Sensors for Measurements in Extremely Alkaline Media

Nurcan Tuncer  1 , Efdal Teknikel  1 , Canan Unaleroglu  2
Affiliations

Rationally Designed Fluorescent pH Sensors for Measurements in Extremely Alkaline Media

Nurcan Tuncer et al. J Fluoresc. 2018 Nov.

Abstract

We investigated the pKa increasing effects on meso-phenol BODIPY to achieve fluorescent pH sensors working in extreme alkalinity. We demonstrated the effects of substituents on meso, α, γ and position of the hydroxyl group on pKa. By considering these parameters, we developed pH sensors working above 11.0 in aqueous medium (ethanol/water 1:1). One of these sensors had a pKa of 12.0 and enabled the measurement of pH up to 13.6. This highly photostable and bright sensor compound could be synthesized easily from cheap starting materials.

Keywords: BODIPY; Fluorescent sensor; High pH; pH sensor.

PubMed Disclaimer

References

    1. Analyst. 2011 Sep 21;136(18):3698-706 - PubMed
    1. ACS Appl Mater Interfaces. 2014 Nov 26;6(22):19515-9 - PubMed
    1. Inorg Chem. 2010 Nov 15;49(22):10606-16 - PubMed
    1. Bioorg Med Chem. 2017 Apr 1;25(7):2167-2176 - PubMed
    1. J Fluoresc. 2014 Nov;24(6):1621-8 - PubMed

LinkOut - more resources