Getting a Genomic View of DNA Replication Stress

Lee Zou¹, Hai Dang Nguyen²

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115. Electronic address: zou.lee@mgh.harvard.edu.
² Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

PMID: 30340018
DOI: 10.1016/j.molcel.2018.10.001

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Getting a Genomic View of DNA Replication Stress

Lee Zou et al. Mol Cell. 2018.

Free article

. 2018 Oct 18;72(2):201-203.

doi: 10.1016/j.molcel.2018.10.001.

Authors

Lee Zou¹, Hai Dang Nguyen²

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115. Electronic address: zou.lee@mgh.harvard.edu.
² Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

PMID: 30340018
DOI: 10.1016/j.molcel.2018.10.001

Abstract

DNA replication forks collapse at numerous sites throughout the genome under replication stress. Studies by Shastri et al. (2018) and Tubbs et al. (2018) used different genomics approaches to map the sites of replication fork collapse, revealing the contribution of specific DNA sequences to replication stress.

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Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.
Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, Jaszczyszyn Y, Aladjem MI, Aplan PD, Hyrien O, Nussenzweig A. Tubbs A, et al. Cell. 2018 Aug 23;174(5):1127-1142.e19. doi: 10.1016/j.cell.2018.07.011. Epub 2018 Aug 2. Cell. 2018. PMID: 30078706 Free PMC article.
Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition.
Shastri N, Tsai YC, Hile S, Jordan D, Powell B, Chen J, Maloney D, Dose M, Lo Y, Anastassiadis T, Rivera O, Kim T, Shah S, Borole P, Asija K, Wang X, Smith KD, Finn D, Schug J, Casellas R, Yatsunyk LA, Eckert KA, Brown EJ. Shastri N, et al. Mol Cell. 2018 Oct 18;72(2):222-238.e11. doi: 10.1016/j.molcel.2018.08.047. Epub 2018 Oct 4. Mol Cell. 2018. PMID: 30293786 Free PMC article.

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Getting a Genomic View of DNA Replication Stress

Affiliations

Getting a Genomic View of DNA Replication Stress

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