Fear Extinction Requires Reward

Sheena A Josselyn¹, Paul W Frankland²

Affiliations

¹ Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Brain, Mind, and Consciousness Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada. Electronic address: sheena.josselyn@sickkids.ca.
² Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada. Electronic address: paul.frankland@sickkids.ca.

PMID: 30340037
DOI: 10.1016/j.cell.2018.09.036

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Fear Extinction Requires Reward

Sheena A Josselyn et al. Cell. 2018.

Free article

. 2018 Oct 18;175(3):639-640.

doi: 10.1016/j.cell.2018.09.036.

Authors

Sheena A Josselyn¹, Paul W Frankland²

Affiliations

¹ Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Brain, Mind, and Consciousness Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada. Electronic address: sheena.josselyn@sickkids.ca.
² Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, ON M5G 1M1, Canada. Electronic address: paul.frankland@sickkids.ca.

PMID: 30340037
DOI: 10.1016/j.cell.2018.09.036

Abstract

Learning theorists long hypothesized that appetitive and aversive motivational states influence one another antagonistically. Here, Felsenberg et al. show that the activity of neurons in Drosophila known to be important in appetitive conditioning is necessary for the extinction of aversive conditioning, thereby uncovering biological evidence for this opponent-process.

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Integration of Parallel Opposing Memories Underlies Memory Extinction.
Felsenberg J, Jacob PF, Walker T, Barnstedt O, Edmondson-Stait AJ, Pleijzier MW, Otto N, Schlegel P, Sharifi N, Perisse E, Smith CS, Lauritzen JS, Costa M, Jefferis GSXE, Bock DD, Waddell S. Felsenberg J, et al. Cell. 2018 Oct 18;175(3):709-722.e15. doi: 10.1016/j.cell.2018.08.021. Epub 2018 Sep 20. Cell. 2018. PMID: 30245010 Free PMC article.

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Fear Extinction Requires Reward

Affiliations

Fear Extinction Requires Reward

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Molecular Biology Databases