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Review
. 2018 Oct 18;10(4):191.
doi: 10.3390/pharmaceutics10040191.

Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Vijay Mishra  1 , Kuldeep K Bansal  2 , Asit Verma  3 , Nishika Yadav  4 , Sourav Thakur  5 , Kalvatala Sudhakar  6 , Jessica M Rosenholm  7
Affiliations
Review

Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Vijay Mishra et al. Pharmaceutics. .

Abstract

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.

Keywords: colloidal nanocarriers; cytotoxicity; solid lipid nanoparticles; targeted drug delivery.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
General structure of solid lipid nanoparticle (SLN) loaded with drug.
Figure 2
Figure 2
Step by step procedure of hot homogenization technique.
Figure 3
Figure 3
Schematic representation of SLN production by microemulsion technique.
Figure 4
Figure 4
Flow chart for solvent emulsification/evaporation method.
Figure 5
Figure 5
Influence of zeta potential on particle-particle interaction.
Figure 6
Figure 6
Models of incorporation of active compounds into SLN.
Figure 7
Figure 7
Schematic representation of applications of SLNs.
See this image and copyright information in PMC

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