Randomized Controlled Trial

. 2018 Oct 19;20(1):124.

doi: 10.1186/s13058-018-1051-6.

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial

Affiliations

¹ Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA. cdieli@usc.edu.
² Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. cdieli@usc.edu.
³ Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
⁴ Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
⁵ Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
⁶ Division of Endocrinology and Diabetes, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
⁷ Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
⁸ Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁹ Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope (COH), Duarte, CA, 91010, USA.
¹⁰ Division of Medical Oncology and Experimental Therapeutics, COH, Duarte, CA, 91010, USA.

PMID: 30340503
PMCID: PMC6194749
DOI: 10.1186/s13058-018-1051-6

Randomized Controlled Trial

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial

Christina M Dieli-Conwright et al. Breast Cancer Res. 2018.

. 2018 Oct 19;20(1):124.

doi: 10.1186/s13058-018-1051-6.

Authors

Affiliations

¹ Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA. cdieli@usc.edu.
² Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. cdieli@usc.edu.
³ Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
⁴ Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
⁵ Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
⁶ Division of Endocrinology and Diabetes, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
⁷ Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
⁸ Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁹ Division of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope (COH), Duarte, CA, 91010, USA.
¹⁰ Division of Medical Oncology and Experimental Therapeutics, COH, Duarte, CA, 91010, USA.

PMID: 30340503
PMCID: PMC6194749
DOI: 10.1186/s13058-018-1051-6

Abstract

Background: Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors.

Methods: One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis.

Results: At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO_2max (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01).

Conclusions: A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care.

Trial registration: This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.

Keywords: Exercise; bone health; breast cancer; physical fitness; quality of life.

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Conflict of interest statement

Ethics approval and consent to participate

The protocol and informed consent were approved (HS-12-00141) by the USC Institutional Review Board.

Consent for publication

A signed informed consent was obtained from each participant. The informed consent is available upon request.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

1. Ording AG, Garne JP, Nystrom PM, Froslev T, Sorensen HT, Lash TL. Comorbid diseases interact with breast cancer to affect mortality in the first year after diagnosis--a Danish nationwide matched cohort study. PLoS One. 2013;8(10):e76013. doi: 10.1371/journal.pone.0076013. - DOI - PMC - PubMed
1. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH. An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv. 2010;4(2):87–100. doi: 10.1007/s11764-009-0110-5. - DOI - PubMed
1. Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, et al. Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial. J Clin Oncol. 2018;36(9):875–883. doi: 10.1200/JCO.2017.75.7526. - DOI - PMC - PubMed
1. Dieli-Conwright CM, Mortimer JE, Schroeder ET, Courneya K, Demark-Wahnefried W, Buchanan TA, et al. Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods. BMC Cancer. 2014;14:238. doi: 10.1186/1471-2407-14-238. - DOI - PMC - PubMed
1. Ebbeling CB, Ward A, Puleo EM, Widrick J, Rippe JM. Development of a single-stage submaximal treadmill walking test. Med Sci Sports Exerc. 1991;23(8):966–973. doi: 10.1249/00005768-199108000-00014. - DOI - PubMed

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Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial

Affiliations

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial

Authors

Affiliations

Abstract

Conflict of interest statement

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

References

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