Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Nov 13;38(6):BSR20180702.
doi: 10.1042/BSR20180702. Print 2018 Dec 21.

The association between rs16917496 T/C polymorphism of SET8 gene and cancer risk in Asian populations: a meta-analysis

Hui-Xia Wei  1 , Guo-Xiang Tian  2 , Ju-Kun Song  3 , Lian-Jie Yang  4 , Yu-Pei Wang  5
Affiliations
Meta-Analysis

The association between rs16917496 T/C polymorphism of SET8 gene and cancer risk in Asian populations: a meta-analysis

Hui-Xia Wei et al. Biosci Rep. .

Abstract

Epidemiological studies have demonstrated close associations between SET8 rs16917496 T/C polymorphism and cancer risk, but the results of published studies were not consistent. We therefore performed this meta-analysis to explore the associations between rs16917496 T/C polymorphism and cancer risk. Five online databases were searched. Odds ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between rs16917496 T/C polymorphism and cancer risk. In addition, heterogeneity, accumulative, sensitivity analysis, and publication bias were conducted to check the statistical power. Overall, 13 publications involving 5878 subjects were identified according to included criteria. No significant cancer risk was observed in genetic model of SET8 rs16917496 T/C polymorphism in Asian populations (C vs. T: OR = 1.04, 95%CI = 0.88-1.23, P = 0.63%; TC vs. TT: OR = 1.17, 95%CI = 0.96-1.24, P = 0.11%; CC vs. TT: OR = 0.90, 95%CI = 0.60-1.37, P = 0.63; TC+CC vs. TT: OR = 1.11, 95%CI = 0.90-1.38, P = 0.33; CC vs. TT+TC: OR = 0.92, 95%CI = 0.65-1.30, P = 0.63). Furthermore, similar associations were found in the subgroup analysis of race diversity, control design, genotyping methods, and different cancer types. In summary, our meta-analysis indicated that the SET8 rs16917496 T/C polymorphism may not play a critical role in cancer development in Asian populations.

Keywords: SET8; cancer; miR-502; polymorphism; rs16917496.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1. Flow diagram of the study selection process
Figure 2
Figure 2. OR and 95% CIs of the associations between SET8 rs16917496 T/C polymorphism and cancer risk in TC+CC vs. TT model
Figure 3
Figure 3. Cumulative meta-analyses according to publication year in TC+CC vs. TT model of SET8 rs16917496 T/C polymorphism
Figure 4
Figure 4. Sensitivity analysis through deleting each study to reflect the influence of the individual dataset to the pooled ORs in TC+CC vs. TT model of SET8 rs16917496 T/C polymorphism
Figure 5
Figure 5. Funnel plot analysis to detect publication bias for TC+CC vs. TT model of SET8 rs16917496 T/C polymorphism
Circles represent the weight of the studies.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J. and Jemal A. (2015) Global cancer statistics, 2012. CA Cancer J. Clin. 65, 87–108 10.3322/caac.21262 - DOI - PubMed
    1. Chen W., Zheng R., Baade P.D., Zhang S., Zeng H., Bray F.. et al. (2016) Cancer statistics in China, 2015. CA Cancer J. Clin. 66, 115–132 10.3322/caac.21338 - DOI - PubMed
    1. Gray K.D., Moore M.D., Panjwani S., Elmously A., Afaneh C., Fahey T.J. III. et al. (2018) Predicting survival and response to treatment in gastroesophageal neuroendocrine tumors: an analysis of the National Cancer Database. Ann. Surg. Oncol. 25, 1418–1424 10.1245/s10434-018-6389-6 - DOI - PubMed
    1. Kirke D.N., Qureshi M.M., Kamran S.C., Ezzat W., Jalisi S., Salama A.. et al. (2018) Role of adjuvant chemoradiotherapy in T4N0 stage IV head and neck cancer: a National Cancer Database analysis. Head Neck 40, 1174–1184 10.1002/hed.25087 - DOI - PubMed
    1. Amsbaugh M.J., Yusuf M., Cash E., Silverman C., Potts K. and Dunlap N. (2018) Effect of time to simulation and treatment for patients with oropharyngeal cancer receiving definitive radiotherapy in the era of risk stratification using smoking and human papillomavirus status. Head Neck 40, 687–695 10.1002/hed.24963 - DOI - PubMed

Publication types

Substances