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. 1987 Mar;31(3):461-2.
doi: 10.1128/AAC.31.3.461.

Effect of calcium on in vitro activity of LY146032 against Clostridium difficile

H Faruki, A C Niles, R L Heeren, P R Murray

Effect of calcium on in vitro activity of LY146032 against Clostridium difficile

H Faruki et al. Antimicrob Agents Chemother. 1987 Mar.

Abstract

The in vitro MICs of LY146032 against 63 isolates of Clostridium difficile tested in Wilkins-Chalgren broth ranged from 0.5 to greater than 32 micrograms/ml, with MICs of 4 and 8 micrograms/ml for 50 and 90% of the isolates, respectively. However, when the test medium was supplemented with physiologic concentrations of calcium, the MIC for 90% of the isolates was reduced to less than or equal to 0.12 microgram/ml.

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References

    1. Antimicrob Agents Chemother. 1976 Dec;10(6):926-8 - PubMed
    1. Antimicrob Agents Chemother. 1985 Mar;27(3):357-62 - PubMed

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