In reply: When and how should we cluster and cross over: methodological and ethical issues (letters 1 and 2)

Cory E Goldstein¹, Bruno Giraudeau^{2

3}, Charles Weijer⁴, Monica Taljaard^{4

5

6}

Affiliations

¹ Rotman Institute of Philosophy, Western University, London, ON, Canada. cgoldst2@uwo.ca.
² Université de Tours, Université de Nantes, INSERM SPHERE, Tours, France.
³ INSERM CIC, CHRU de Tours, Tours, France.
⁴ Rotman Institute of Philosophy, Western University, London, ON, Canada.
⁵ Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁶ School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Comment

Cory E Goldstein et al. Can J Anaesth. 2019 Feb.

. 2019 Feb;66(2):239-240.

doi: 10.1007/s12630-018-1239-3. Epub 2018 Oct 19.

Cory E Goldstein¹, Bruno Giraudeau^{2

3}, Charles Weijer⁴, Monica Taljaard^{4

5

6}

¹ Rotman Institute of Philosophy, Western University, London, ON, Canada. cgoldst2@uwo.ca.
² Université de Tours, Université de Nantes, INSERM SPHERE, Tours, France.
³ INSERM CIC, CHRU de Tours, Tours, France.
⁴ Rotman Institute of Philosophy, Western University, London, ON, Canada.
⁵ Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁶ School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

No abstract available

Comment on

The role of randomized cluster crossover trials for comparative effectiveness testing in anesthesia: design of the Benzodiazepine-Free Cardiac Anesthesia for Reduction in Postoperative Delirium (B-Free) trial.
Spence J, Belley-Côté E, Lee SF, Bangdiwala S, Whitlock R, LeManach Y, Syed S, Lamy A, Jacobsohn E, MacIsaac S, Devereaux PJ, Connolly S. Spence J, et al. Can J Anaesth. 2018 Jul;65(7):813-821. doi: 10.1007/s12630-018-1130-2. Epub 2018 Apr 18. Can J Anaesth. 2018. PMID: 29671186 English.
When and how should we cluster and cross over: methodological and ethical issues.
Goldstein CE, Giraudeau B, Weijer C, Taljaard M. Goldstein CE, et al. Can J Anaesth. 2018 Jul;65(7):760-765. doi: 10.1007/s12630-018-1131-1. Epub 2018 May 4. Can J Anaesth. 2018. PMID: 29728919 Free PMC article. No abstract available.
When and how should we cluster and cross over: methodological and ethical issues (letter 1).
Spence J, Belley-Côté E, Oczkowski S, Jacobsohn E, Whitlock R, Devereaux PJ, Connolly S. Spence J, et al. Can J Anaesth. 2019 Feb;66(2):234-236. doi: 10.1007/s12630-018-1237-5. Epub 2018 Oct 17. Can J Anaesth. 2019. PMID: 30334190 No abstract available.
When and how should we cluster and cross over: methodological and ethical issues (letter 2).
Lee SF, Bangdiwala SI, Spence J, Connolly S. Lee SF, et al. Can J Anaesth. 2019 Feb;66(2):237-238. doi: 10.1007/s12630-018-1238-4. Epub 2018 Oct 19. Can J Anaesth. 2019. PMID: 30341666 No abstract available.

1. Spence J, Belley-Côté E, Lee SF, et al. The role of randomized cluster crossover trials for comparative effectiveness testing in anesthesia: design of the Benzodiazepine-Free Cardiac Anesthesia for Reduction in Postoperative Delirium (B-Free) trial. Can J Anesth 2018; 65: 813-21. - DOI - PubMed
1. Goldstein CE, Giraudeau B, Weijer C, Taljaard M. When and how should we cluster and cross over: methodological and ethical issues. Can J Anesth 2018; 65: 760-5. - DOI - PubMed
1. Lee SF, Bangdiwala SI, Spence J, Connolly S. When and how should we cluster and cross over: methodological and ethical issues (letter 2). Can J Anesth 2018; 65: DOI: https://doi.org/10.1007/s12630-018-1238-4
1. Spence J, Belley-Côté E, Ozchowski S, et al. When and how should we cluster and cross over: methodological and ethical issues (letter 1). Can J Anesth 2018; 65: DOI: https://doi.org/10.1007/s12630-018-1237-5 .
1. Edwards SJ, Braunholtz DA, Lilford RJ, Stevens AJ. Ethical issues in the design and conduct of cluster randomised controlled trials. BMJ 1999; 318: 1407-9. - DOI - PubMed - PMC