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. 1978 Jul-Aug;57(4):478-80.
doi: 10.1213/00000539-197807000-00019.

Effects of pH on protein binding of lidocaine

R G Burney, C A DiFazio, J A Foster

Effects of pH on protein binding of lidocaine

R G Burney et al. Anesth Analg. 1978 Jul-Aug.

Abstract

Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations.

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