Bronchoprovocation Testing in Asthma: An Update

Abstract

Bronchial hyperresponsiveness (BHR) is defined as a heightened bronchoconstrictive response to airway stimuli. It complements the cardinal features in asthma, such as variable or reversible airflow limitation and airway inflammation. Although BHR is considered a pathophysiologic hallmark of asthma, it should be acknowledged that this property of the airway is dynamic, because its severity and even presence can vary over time with disease activity, triggers or specific exposure, and with treatment. In addition, it is important to recognize that there is a component that is not reflective of a specific disease entity.

Keywords: Airway inflammation; Airway remodeling; Asthma; Bronchial hyperresponsiveness; Bronchoprovocation challenges; Bronchoprovocation testing.