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Case Reports
. 2018 Oct;57(5):750-752.
doi: 10.1016/j.tjog.2018.08.026.

Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy

Kengo Hiranuma  1 , Soshi Kusunoki  2 , Kazunari Fujino  3 , Takashi Hirayama  4 , Tsuyoshi Ota  5 , Yasuhisa Terao  6
Affiliations
Case Reports

Drug-induced aortitis in a patient with ovarian cancer treated with bevacizumab combination therapy

Kengo Hiranuma et al. Taiwan J Obstet Gynecol. 2018 Oct.

Abstract

Objective: To review and evaluate drug-induced vasculitis, which is an extremely rare complication of chemotherapy.

Case report: A 47-year-old woman with ovarian cancer developed aortitis during bevacizumab combination chemotherapy. Contract-enhanced CT showed concentric thickening of the descending aorta. Antibiotics were administered, but a repeat CE-CT scan showed no resolution of the aortitis. To treat the aortitis, she was started on oral prednisolone. A subsequent CE-CT scan showed no signs of aortitis. She was thus re-started on a modified chemotherapy regimen.

Conclusion: Aortitis should be considered in patients receiving bevacizumab combination therapy who develop persistent fever and upper-abdominal pain. Contrast-enhanced CT is useful for detecting drug-induced aortitis.

Keywords: Aortitis; Bevacizumab; G-CSF; Ovarian cancer.

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