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Comment
. 2018 Dec:76:137-139.
doi: 10.1016/j.ceca.2018.10.002. Epub 2018 Oct 12.

The multifaceted STAT3: How a transcription factor regulates Ca2+ signaling via a degradative pathway

Jan B Parys  1
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Comment

The multifaceted STAT3: How a transcription factor regulates Ca2+ signaling via a degradative pathway

Jan B Parys. Cell Calcium. 2018 Dec.

Abstract

STAT3 is a pleiotropic prosurvival transcription factor with functions in nucleus and mitochondria. Avalle et al. (Cell Death Diff., 2018) now present evidence that STAT3 also promotes IP3R3 degradation at the endoplasmic reticulum, thereby limiting Ca2+ transfer to the mitochondria and thus supporting cellular survival via an alternate pathway.

Keywords: Apoptosis; ER-mitochondria contact sites; IP(3) receptor; Oncogenes; STAT3.

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