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. 2019 Jan;139(1):61-72.
doi: 10.1007/s00402-018-3048-0. Epub 2018 Oct 20.

Insights into treatment and outcome of fracture-related infection: a systematic literature review

H Bezstarosti  1 , E M M Van Lieshout  1 , L W Voskamp  1 , K Kortram  1 , W Obremskey  2 , M A McNally  3 , W J Metsemakers  4 , M H J Verhofstad  5
Affiliations

Insights into treatment and outcome of fracture-related infection: a systematic literature review

H Bezstarosti et al. Arch Orthop Trauma Surg. 2019 Jan.

Abstract

Introduction: Standardized guidelines for treatment of fracture-related infection (FRI) are lacking. Worldwide many treatment protocols are used with variable success rates. Awareness on the need of standardized, evidence-based guidelines has increased in recent years. This systematic literature review gives an overview of available diagnostic criteria, classifications, treatment protocols, and related outcome measurements for surgically treated FRI patients.

Methods: A comprehensive search was performed in all scientific literature since 1990. Studies in English that described surgical patient series for treatment of FRI were included. Data were collected on diagnostic criteria for FRI, classifications used, surgical treatments, follow-up protocols, and overall outcome. A systematic review was performed according to the PRISMA statement. Proportions and weighted means were calculated.

Results: The search yielded 2051 studies. Ninety-three studies were suitable for inclusion, describing 3701 patients (3711 fractures) with complex FRI. The population consisted predominantly of male patients (77%), with the tibia being the most commonly affected bone (64%), and a mean of three previous operations per patient. Forty-three (46%) studies described FRI at one specific location. Only one study (1%) used a standardized definition for infection. A total of nine different classifications were used to guide treatment protocols, of which Cierny and Mader was used most often (36%). Eighteen (19%) studies used a one-stage, 50 (54%) a two-stage, and seven (8%) a three-stage surgical treatment protocol. Ten studies (11%) used mixed protocols. Antibiotic protocols varied widely between studies. A multidisciplinary approach was mentioned in only 12 (13%) studies.

Conclusions: This extensive literature review shows a lack of standardized guidelines with respect to diagnosis and treatment of FRI, which mimics the situation for prosthetic joint infection identified many years ago. Internationally accepted guidelines are urgently required to improve the quality of care for patients suffering from this significant complication.

Keywords: Classification; Definition; Diagnosis; Fracture-related infection; Outcome measurements; Treatment.

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Conflict of interest statement

Conflict of interest

The authors have no conflicts of interest to disclose.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was not applicable in this study.

Figures

Fig. 1
Fig. 1
Flowchart of the study
See this image and copyright information in PMC

References

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