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. 2019 Feb;55(2):93-99.
doi: 10.1016/j.arbres.2018.07.026. Epub 2018 Oct 19.

The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease

[Article in English, Spanish]
Joaquim Gea  1 , Sergi Pascual  2 , Ady Castro-Acosta  3 , Carmen Hernández-Carcereny  4 , Robert Castelo  5 , Eduardo Márquez-Martín  6 , Concepción Montón  7 , Alexandre Palou  8 , Rosa Faner  4 , Laura I Furlong  5 , Luis Seijo  9 , Ferran Sanz  5 , Montserrat Torà  10 , Carles Vilaplana  11 , Carme Casadevall  2 , José Luis López-Campos  6 , Eduard Monsó  7 , Germán Peces-Barba  12 , Borja G Cosío  8 , Alvar Agustí  4 ; en representación del grupo BIOMEPOC; Anexo. Miembros del grupo BIOMEPOC
Collaborators, Affiliations

The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease

[Article in English, Spanish]
Joaquim Gea et al. Arch Bronconeumol (Engl Ed). 2019 Feb.

Abstract

Chronic obstructive pulmonary disease (COPD) is an entity with a heterogeneous presentation. For this reason, attempts have been made to characterize different phenotypes and endotypes to enable a more individualized approach. The aim of the Biomarkers in COPD (BIOMEPOC) project is to identify useful biomarkers in blood to improve the characterization of patients. Clinical data and blood samples from a group of patients and healthy controls will be analyzed. The project will consist of an exploration phase and a validation phase. Analytical parameters in blood will be determined using standard techniques and certain 'omics' (transcriptomics, proteomics, and metabolomics). The former will be hypothesis-driven, whereas the latter will be exploratory. Finally, a multilevel analysis will be conducted. Currently, 269 patients and 83 controls have been recruited, and sample processing is beginning. Our hope is to use the results to identify new biomarkers that, alone or combined, will allow a better characterization of patients.

Keywords: Análisis multinivel; Biological markers; COPD; EPOC; Endotipos; Endotypes; Marcadores biológicos; Medicina personalizada; Multilevel analysis; Personalized medicine.

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